Peroxisome Proliferator-Activator Receptor Alpha (PPARalpha)

PPARalpha receptors are nuclear receptors that function as transcription factors. PPARalpha receptors are activated by free fatty acids, eicosanoids, PGJ2 (a prostaglandin), and also leukotriene B4. PPARalpha receptors are involved in insulin resistance, cholesterol metabolism and lipid metabolism.